Scientific foundation

Human behavior occurs in seconds. Neuronal learning occurs in milliseconds.

Mentalness is built on the principle that the brain learns through timed, repeated, multisensory experience. The SMM hypothesis is that synchronization—not stimulation alone—is the differentiator.

U.S. Patent Application Published The Mentalness Synchronized Multisensory Method has reached published U.S. patent-application status, reinforcing the platform’s IP foundation as validation advances.

The scientific message

From stimulation to a learning loop.

Medication can modulate pathways and behavioral therapy can guide action, but many interventions do not teach the brain what to do immediately after the stimulus. SMM synchronizes sensory stimulus with cognitive elaboration, execution, feedback and repetition in a structured protocol.

From sensory stimulation to a synchronized neuronal learning loop

Neuronal learning protocol

Cue → attend → encode → reinforce → measure.

01

Cue

Five-channel multisensory input creates a salient starting signal for attention and task engagement.

02

Attend

Synchronization is used to support sustained attention at the moment the protocol begins.

03

Encode

The user performs a structured cognitive task involving memory, inhibition, decision-making or executive control.

04

Reinforce

Repeated experiences build association, reward, feedback and procedural familiarity.

05

Measure

Physiological, behavioral and cognitive markers track response, tolerability and progression.

Measurable brain-health signals and objective outcome model

Objective outcome model

Not self-perceived wellness alone. Measurable signals.

Planned endpoints include cognitive function, brain structure and connectivity, neurodegenerative markers, gamma EEG activity, evoked potentials, session completion, fatigue, safety, adherence and engagement.

Research context

Gamma-frequency stimulation is promising, but still a research field.

Published research has explored 40 Hz gamma sensory stimulation in preclinical models and early human studies. Mentalness treats this as scientific context for responsible validation — not as an established treatment claim.

Iaccarino et al.Gamma entrainment and amyloid load — Nature, 2016. Martorell et al.Multi-sensory gamma stimulation — Cell, 2019. Chan et al.40 Hz sensory stimulation feasibility — 2022. Murdock et al.Multisensory gamma and glymphatic mechanisms — Nature, 2024.

Scientific leadership

A foundation built over decades.

Mentalness is grounded in work led by Prof. Tomás Ortiz Alonso, MD, PhD, at Universidad Complutense de Madrid, with decades of research experience in neuroplasticity, multisensory stimulation, EEG, gamma synchrony and memory circuits.

“The differentiator is synchronization in milliseconds, not just stimulation.”

Mentalness scientific thesis

Scientific references are included as context for the field. They do not represent completed clinical evidence for Mentalness products. Mentalness protocols require prospective validation.