Brain health / MCI research direction
Responsible early validation for MCI and aging-associated cognitive decline.
Mentalness is exploring whether repeated, synchronized multisensory neuronal learning can support memory processes and generate objective signals in MCI and aging-associated cognitive decline. This is a research direction, not a treatment claim.
Why this matters
The gap is post-stimulation learning.
The central hypothesis is that a structured learning loop — sensory cue, attention, memory task, reinforcement, feedback and repetition — may create measurable functional signals beyond passive stimulation or generic wellness content.
Repeated, non-invasive, synchronized multisensory sessions to generate measurable cognitive and neural signals.
Mentalness core propositionFeasibility concept
30–50 subjects · 12 months · scientific signal detection.
Protocol design
PI alignment, safety review, endpoint selection, device integration and responsible language.
Recruitment
MCI or early cognitive-decline criteria refined with scientific and clinical advisors.
Sessions
Structured sessions with adherence, tolerability and response tracking.
Analysis
Cognition, EEG, MRI/fMRI, PET and/or plasma biomarkers, depending on partner capabilities.
Publication package
Manuscript, conference abstract, data package and next-trial design.
Outcome model
What we would measure.
Cognitive function
Attention, short- and long-term memory, executive control, processing speed and validated cognitive scales.
Connectivity
MRI/fMRI network changes, structural measurements and functional connectivity signals.
Biomarkers
PET, nuclear medicine and/or plasma biomarker panels where appropriate and feasible.
EEG
Gamma EEG activity, evoked potentials and cognitive-state markers.
Safety + adherence
Session completion, fatigue, tolerability, engagement and caregiver context where relevant.
Collaboration model
Protocol science in Spain + data rigor in the U.S.
The proposed model combines SMM protocol design and memory-sequencing expertise with an academic or clinical research partner for IRB, data acquisition, imaging access, endpoint selection and publication strategy.
Collaborate on researchMentalness is not an approved Alzheimer’s treatment. This page describes planned research and feasibility design for scientific review.